Select Publications

2024

Vincent KF, Park GH, Stapley BM, Dillon EJ, Solt K. Methylphenidate Reversal of Dexmedetomidine-Induced Versus Ketamine-Induced Sedation in Rats. Anesth Analg. 2024 Aug 7. doi: 10.1213/ANE.0000000000007085. Epub ahead of print. PMID: 39110627.

Fettiplace MR, Vincent KF, Cho A, Dillon E, Stapley BM, Stewart V, Solt K. Dopaminergic psychostimulants cause arousal from isoflurane-induced sedation without reversing memory impairment in rats. Br J Anaesth. 2024 Jul 3:S0007-0912(24)00336-2. doi: 10.1016/j.bja.2024.05.026. Epub ahead of print. PMID: 38965013.

Vincent KF, Zhang ER, Cho AJ, Kato-Miyabe R, Mallari OG, Moody OA, Obert DP, Park GH, Solt K. Electrical stimulation of the ventral tegmental area restores consciousness from sevoflurane-, dexmedetomidine-, and fentanyl-induced unconsciousness in rats. Brain Stimul. 2024 May-Jun;17(3):687-697. doi: 10.1016/j.brs.2024.05.012. Epub 2024 May 29. PMID: 38821397; PMCID: PMC11212499.

Cylinder DM, van Zundert AAJ, Solt K, van Swinderen B. Time to Wake Up! The Ongoing Search for General Anesthetic Reversal Agents. Anesthesiology. 2024 Mar 1;140(3):610-627. doi: 10.1097/ALN.0000000000004846. PMID: 38349760; PMCID: PMC10868874.

2023

Vincent KF, Solt K. Modulating anesthetic emergence with pathway-selective dopamine signaling. Current Opinion in Anaesthesiology. 2023 Oct 1;36(5):468-475. doi: 10.1097/ACO.0000000000001293. PMID: 37552017

Vincent KF, Mallari OG, Dillon EJ, Stewart VG, Cho AJ, Dong Y, Edlow AG, Ichinose F, Xie Z, Solt K. Oestrous cycle affects emergence from anaesthesia with dexmedetomidine, but not propofol, isoflurane, or sevoflurane, in female rats. British Journal of Anaesthesia. 2023 Jul;131(1):67-78. doi: 10.1016/j.bja.2023.03.025. PMID: 37142466; PMCID: PMC10308440

2022

Takamitsu I, Edilberto A, Yusuke M, Risako K, Eizo M, Michael GS, Rajeev M, Ken S, Fumito I. Post–cardiac arrest Sedation Promotes Electroencephalographic Slow-wave Activity and Improves Survival in a Mouse Model of Cardiac Arrest. Anesthesiology. 2022; 137:716–732. doi: 10.1097/ALN.0000000000004390. PMID: 36170545

Barra ME, Edlow BL, Lund JT, DeSanctis KS, Vetrano J, Reilly-Tremblay C, Zhang ER, Bodien YG, Brown EN, Solt K. Stability of extemporaneously prepared preservative-free methylphenidate 5 mg/mL intravenous solution. American Journal of Health-System Pharmacy. 2022 Feb 18;79(5):359-363. doi: 10.1093/ajhp/zxab420. PMID: 34788364

2021

Vincent KF, Zhang ER, Kato R, Cho A, Moody OA, Solt K. Return of the Righting Reflex Does Not Portend Recovery of Cognitive Function in Anesthetized Rats. Frontiers in Systems Neuroscience. 2021 Nov 18;15:762096. doi: 10.3389/fnsys.2021.762096. PMID: 34867222 [PDF]

Barra ME, Edlow BL, Lund JT, DeSanctis KS, Vetrano J, Reilly-Tremblay C, Zhang ER, Bodien YG, Brown EN, Solt K. Stability of extemporaneously prepared preservative-free methylphenidate 5 mg/mL intravenous solution. American Journal of Health-System Pharmacy. 2021 Nov 11;zxab420. doi: 10.1093/ajhp/zxab420. PMID: 34788364

Moody OA, Vincent KF, Solt K. Sex, drugs, and anaesthesia research. British Journal of Anaesthesia. 2021 Sep;127(3):340-343. doi: 10.1016/j.bja.2021.06.025. PMID: 34330415

Melonakos ED, Siegmann MJ, Rey C, O’Brien C, Nikolaeva KK, Solt K, Nehs CJ. Excitation of Putative Glutamatergic Neurons in the Rat Parabrachial Nucleus Region Reduces Delta Power during Dexmedetomidine but not Ketamine Anesthesia. Anesthesiology. 2021 Oct 1;135(4):633-648. doi: 10.1097/ALN.0000000000003883. PMID: 34270686 [PDF]

Kato R, Zhang ER, Mallari OG, Moody OA, Vincent KF, Melonakos ED, Siegmann MJ, Nehs CJ, Houle TT, Akeju O, Solt K. D-Amphetamine Rapidly Reverses Dexmedetomidine-Induced Unconsciousness in Rats. Frontiers in Pharmacology. 2021 May 18;12:668285. doi: 10.3389/fphar.2021.668285 [PDF]

Kato R, Solt K. Prehabilitation With Brain Stimulation? Anesthesia & Analgesia. 2021 May 1;132(5):1344-1346. doi: 10.1213/ANE.0000000000005454. PMID: 33857977

Moody OA, Zhang ER, Vincent KF, Kato R, Melonakos ED, Nehs CJ, Solt K. The Neural Circuits Underlying General Anesthesia and Sleep. Anesthesia & Analgesia. 2021 May 1;132(5):1254-1264. doi: 10.1213/ANE.0000000000005361. PMID: 33857967 [PDF]

Vlasov K, Pei J, Nehs CJ, Guidera JA, Zhang ER, Kenny JD, Houle TT, Brenner GJ, Taylor NE, Solt K. Activation of GABAergic Neurons in the Rostromedial Tegmental Nucleus and Other Brainstem Regions Promotes Sedation and Facilitates Sevoflurane Anesthesia in Mice. Anesthesia & Analgesia. 2021 Apr 1;132(4):e50-e55. doi: 10.1213/ANE.0000000000005387. PMID: 33560660

2020

Moody OA, Zhang ER, Arora V, Kato R, Cotten JF, Solt K. D-Amphetamine Accelerates Recovery of Consciousness and Respiratory Drive After High-Dose Fentanyl in Rats. Frontiers in Pharmacology. 2020 Nov 12;11:585356. doi: 10.3389/fphar.2020.585356. PMID: 33424595 [PDF]

Solt K, Akeju O. The brain rhythms that detach us from reality. Nature. 2020 Oct;586(7827):31-32. doi: 10.1038/d41586-020-02505-z. PMID: 32939081 [PDF]

Edlow BL, Barra ME, Zhou DW, Foulkes AS, Snider SB, Threlkeld ZD, Chakravarty S, Kirsch JE, Chan ST, Meisler SL, Bleck TP, Fins JJ, Giacino JT, Hochberg LR, Solt K, Brown EN, Bodien YG. Personalized connectome mapping to guide targeted therapy and promote recovery of consciousness in the intensive care unit. Neurocritical Care. 2020 Oct;33(2):364-375. doi: 10.1007/s12028-020-01062-7. PMID: 32794142 [PDF]

Melonakos ED, Moody OA, Nikolaeva K, Kato R, Nehs CJ, Solt K. Manipulating Neural Circuits in Anesthesia Research. Anesthesiology. 2020 Jul;133(1):19-30. doi: 10.1097/ALN.0000000000003279. PMID: 32349073 [PDF]

2019

Taylor NE, Long H, Pei J, Kukutla P, Phero A, Hadaegh F, Abdelnabi A, Solt K, Brenner G. The rostromedial tegmental nucleus: A key modulator of pain and opioid analgesia. Pain. 2019;160(11):2524-2534. doi: 10.1097/j.pain.0000000000001647. PMID: 31246732 [PDF]

Hemmings HC, Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA. Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery. Trends in Pharmacological Sciences. 2019;40(7):464-481. doi: 10.1016/j.tips.2019.05.001. PMID: 31147199 [PDF]

Yang Y, Lee JT, Guidera JA, Vlasov KY, Pei J, Brown EN, Solt K, Shanechi MM. Developing a personalized closed-loop controller of medically-induced coma in a rodent model. Journal of Neural Engineering. 2019;16(3):036022. doi: 10.1088/1741-2552/ab0ea4. PMID: 30856619

Kelz MB, Garcia PS, Mashour GA, Solt K. Escape from oblivion: Neural mechanisms of emergence from general anesthesia. Anesthesia & Analgesia. 2019;128(4):726-736. doi: 10.1213/ANE.0000000000004006. PMID: 30883418 [PDF]

Taylor NE, Pei J, Vlasov K, Davis T, Taylor E, Weng F, Van Dort CJ, Solt K, Brown EN. The role of glutamatergic and dopaminergic neurons in the periaqueductal gray/dorsal raphe: Separating analgesia and anxiety. eNeuro. 2019;6(1):e0018-18.2019. doi: 10.1097/j.pain.0000000000001647. PMID: 31058210 [PDF]

2018

Solt K. Using anesthesia to reveal the elements of consciousness. Trends in Cognitive Sciences. 2018;22(11): 961-962. doi: 10.1016/j.tics.2018.07.016. PMID: 30104140 [PDF]

Vlasov K, Van Dort CJ, Solt K. Optogenetics and Chemogenetics. Methods in Enzymology. 2018;603: 181-196. doi: 10.1016/bs.mie.2018.01.022. PMID: 29673525 [PDF]

Zhang H, Zhao H, Zeng C, Van Dort C, Faingold CL, Taylor NE, Solt K, Feng HJ. Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse SUDEP model. Neurobiology of Disease. 2018;110:47- 58. doi: 10.1016/j.nbd.2017.11.003. PMID: 29141182 [PDF]

Plummer GS, Ibala R, Hahm E, An J, Gitlin J, Deng H, Shelton KT, Solt K, Qu JZ, Akeju O. Electroencephalogram dynamics during general anesthesia predict the later incidence and duration of burst-suppression during cardiopulmonary bypass. Clinical Neurophysiology. 2018;130(1):55-60. doi: 10.1016/j.clinph.2018.11.003. PMID: 30476711 [PDF]

2017

An J, Purdon PL, Solt K, Sims NM, Brown EN, Westover MB. Design, implementation, and evaluation of a physiological closed-loop control device for medically-induced coma. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2017:4313-4316. doi: 10.1109/EMBC.2017.8037810. PMID: 29060851 [PDF]

Guidera JA, Taylor NE, Lee JT, Vlasov KY, Pei J, Stephen EP, Mayo JP, Brown EN, Solt K. Sevoflurane induces coherent slow-delta oscillations in rats. Frontiers in Neural Circuits. 2017;11:36. doi: 10.3389/fncir.2017.00036. PMID: 28725184 [PDF]

Nagasaka Y, Wepler M, Thoonen R, Sips PY, Allen K, Graw JA, Yao V, Burns SM, Muenster S, Brouckaert P, Miller K, Solt K, Buys ES, Ichinose F, Zapol WM. Sensitivity to sevoflurane anesthesia is decreased in mice with a congenital deletion of guanylyl cyclase-1 alpha. BMC Anesthesiology. 2017;17(1):76. doi: 10.1186/s12871-017-0368-5. PMID: 28615047 [PDF]

2016

Taylor NE, Van Dort CJ, Kenny JD, Pei J, Guidera JA, Lee JT, Vlasov KY, Boyden ES, Brown EN, Solt K. Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia. Proceedings of the National Academy of Sciences. 2016;113(45):12826–12831. doi: 10.1073/pnas.1614340113. PMID: 27791160 [PDF]

Kenny JD, Chemali JJ, Cotten JF, Van Dort CJ, Kim SE, Ba D, Taylor NE, Brown EN, Solt K. Physostigmine and methylphenidate induce distinct arousal states during isoflurane general anesthesia in rats. Anesthesia & Analgesia. 2016;123(5):1210-1219. doi: 10.1213/ANE.0000000000001234. PMID: 26991753 [PDF]

Muindi F, Kenny JD, Taylor NE, Solt K, Wilson MA, Brown EN, Van Dort CJ. Electrical stimulation of the parabrachial nucleus induces reanimation from isoflurane general anesthesia. Behavioural Brain Research. 2016;306:20-25. doi: 10.1016/j.bbr.2016.03.021. PMID: 26971629

2015

Chemali JJ, Kenny JD, Olutola O, Taylor NE, Kimchi EY, Purdon PL, Brown EN, Solt K. Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain. The British Journal of Anaesthesia. 2015;115(suppl 1): i58-i65. doi: 10.1093/bja/aev112. PMID: 26174302. [PDF]

Kenny JD, Taylor NE, Brown EN, Solt K. Dextroamphetamine (but not atomoxetine) induces reanimation from general anesthesia: Implications for the roles of dopamine and norepinephrine in active emergence. PLOS One. 2015;10(7):e0131914. doi: 10.1371/journal.pone.0131914. PMID: 26148114. [PDF]

Lee JS, Solt K. Intravenous and inhalation anesthetics. In: Pino RM, ed. Clinical anesthesia procedures of the Massachusetts General Hospital, 9th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2015. p. 162-176.

2014

Kenny JD, Westover MB, Ching S, Brown EN, Solt K. Propofol and sevoflurane induce distinct burst suppression patterns in rats. Frontiers in System Neuroscience. 2014;8:237. doi: 10.3389/fnsys.2014.00237 PMID: 25565990. [PDF]

Solt K, Van Dort CJ, Chemali JJ, Taylor NE, Kenny JD, Brown EN. Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia. Anesthesiology. 2014;121(2): 311-9. doi: 10.1097/ALN.0000000000000117. PMID: 24398816. [PDF]

Brown EN, Solt K, Purdon PL, Johnson-Akeju O. Monitoring brain state during general anesthesia and sedation. In: Miller RD, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Cohen NH, eds. Miller’s Anesthesia, 8th ed. Philadelphia, PA: Elsevier; 2014. p. 1524-1540.

2013

Shanechi M, Chemali JJ, Liberman MY, Solt K, Brown EN. A brain-machine interface for control of medically-induced coma. PLOS Computational Biology. 2013;9(10):e1003284. doi: 10.1371/journal.pcbi.1003284. PMID: 24204231. [PDF]

Chemali JJ, Ching S, Purdon PL, Solt K, Brown EN. Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression. Journal of Neural Engineering. 2013;10(5):056017. doi: 10.1088/1741-2560/10/5/056017. PMID: 24018288. [PDF]