Selected Publications

Our research at the Massachusetts General Hospital

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Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats Guidera JA, Taylor, NE, Lee JT, Vlasov KY, Pei JZ, Stephen EP, Mayo JP, Brown EN, Solt K
Frontiers in Neural Circuits 11:36, 2017. doi: 10.3389/fncir.2017.00036 [PDF]


Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats
Kenny JD, Chemali JJ, Cotten JF, Van Dort CJ, Kim SE, Ba D, Taylor NE, Brown EN
Neuroscience and Neuroanesthesiology 123:1210–9, 2016. doi: 10.1213/ANE.0000000000001234 [PDF]

Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia Taylor NE, Van Dort CJ, Kenny JD, Pei JZ, Guidera JA, Vlasov KY, Lee JT, Boyden ES, Brown EN, Solt K
Proceedings of the National Academy of Science 113 (45) 12826-12831. doi: 10.1073/pnas.1614340113 [PDF]


Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain
Chemali JJ, Kenny JD, Olutola O, Taylor NE, Kimchi EY, Purdon PL, Brown EN, Solt K
British Journal of Anaesthesia i58–i65, 2015. doi: 10.1093/bja/aev112 [PDF]

Dextroamphetamine (but Not Atomoxetine) Induces Reanimation from General Anesthesia: Implications for the Roles of Dopamine and Norepinephrine in Active Emergence
Kenny JD, Taylor NE, Brown EN, Solt K
PLoS One 10(7):e0131914, 2015. PMID: 26148114. doi: 10.1371/journal.pone.0131914 [PDF]


Propofol and sevoflurane induce distinct burst suppression patterns in rats
Kenny JD, Westover MB, Ching S, Brown EN, Solt K
Frontiers in System Neuroscience 8:237, 2014. PMID: 25565990. doi: 10.3389/fnsys.2014.00237 [PDF]

Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia
Solt K, Van Dort CJ, Chemali JJ, Taylor NE, Kenny JD, Brown EN
Anesthesiology 121(2):311-319, 2014. PMID: 243988160. doi: 10.1097/ALN.0000000000000117 [PDF]


Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression
Chemali JJ, Ching S, Purdon PL, Solt K, Brown EN
Journal of Neural Engineering 10(5):056017, 2013. PMID: 24018288. doi: 10.1088/1741-2560/10/5/056017 [PDF]

Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia
Taylor NE, Chemali JJ, Brown EN, Solt K
Anesthesiology 118(1):30-39, 2013. PMID: 23221866. doi: 10.1097/ALN.0b013e318278c896 [PDF]

Real-time closed-loop control in a rodent model of medically induced coma using burst suppression
Ching S, Liberman MY, Chemali JJ, Westover MB, Kenny JD, Solt K, Purdon PL, Brown EN.
Anesthesiology 119(4):848-860, 2013. PMID: 23770601. doi: 10.1097/ALN.0b013e31829d4ab4 [PDF]

A brain-machine interface for control of medically-induced coma
Shanechi MM, Chemali JJ, Liberman M, Solt K, Brown EN
PLoS Computational Biology 9(10)e1003284, 2013. PMID: 24204231. doi: 10.1371/journal.pcbi.1003284 [PDF]


General anesthesia: activating a sleep switch?
Solt K
Current Biology 22(21):R918-R919, 2012. PMID: 23137688. doi: 10.1016/j.cub.2012.09.033 [PDF]

Case records of the Massachusetts General Hospital. Case 40-2012. A 43-year-old woman with cardiorespiratory arrest after a cesarean section.
Ecker JL, Solt K, Fitzsimons MG, MacGillivray TE.
New England Journal of Medicine 367(26):2528-36, 2012. PMID: 23268668. doi: 10.1056/NEJMcpc1201413 [PDF]

Active emergence from propofol general anesthesia is induced by methylphenidate
Chemali JJ, Van Dort CJ, Brown EN, Solt K
Anesthesiology 116(5):998-1005, 2012. PMID: 22446983. doi: 10.1097/ALN.0b013e3182518bfc [PDF]


Methylphenidate actively induces emergence from general anesthesia
Solt K, Cotten JF, Cimenser A, Wong KF, Chemali JJ, Brown EN
Anesthesiology 115(5):791-803, 2011. PMID: 21934407. doi: 10.1097/ALN.0b013e31822e92e5 [PDF]


Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity
Solt K, Kelly EW, Cotten JF, Raines DE
Anesthesia and Analgesia 110(2):455-460, 2010. PMID: 19917625. doi: 10.1213/ANE.0b013e3181c5f689 [PDF]


Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model
Solt K, Ruesch D, Forman SA, Davies PA, Raines DE
The Journal of Neuroscience 27(48):13151-13160, 2007. PMID: 18045909 [PDF]

Correlating the clinical actions and molecular mechanisms of general anesthetics
Solt K, Forman SA
Current Opinion in Anesthesiology 20(4):300-306, 2007. PMID: 17620835 [PDF]


Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anesthetics
Solt K, Eger El II, Raines DE
Anesthesia and Analgesia 102(5):1407-1411, 2006. PMID: 16632818 [PDF]

Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein
Solt K, Johansson JS, Raines DE
Biochemistry 45(5):1435-1441, 2006. PMID: 16445285 [PDF]


General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition
Solt K, Stevens RJ, Davies PA, Raines DE
The Journal of Pharmacology and Experimental Therapeutics 315(2):771-776, 2005. PMID: 16081679 [PDF]


Binding of the active metabolite of chloral hydrate, 2,2,2-trichloroethanol, to serum albumin demonstrated using tryptophan fluorescence quenching
Solt K, Johansson JS
Pharmacology 64(3):152-159, 2002. PMID: 11834892 [PDF]